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mardi 25 avril 2017

Capillary-assisted bipolar electrochemistry: a focused minireview

L. Bouffier, N. Sojic, A. Kuhn

Electrophoresis, 2017, in press

A bipolar electrode is quite unconventional as it behaves simultaneously as an anode and a cathode in contrast to a classic electrochemical setup where the electron-transfer reactions are promoted on two different electrodes. The driving force is the polarization potential established between the solution and the bipolar electrode which allows a wireless electrochemical addressing. In the past decade or so, bipolar electrochemistry (BPE) has encountered a remarkable renewal of interest with extraordinary potentialities ranging from materials science to analytical chemistry. For practical reasons, BPE experiments are very often performed in home-made electrochemical cells comprising tubes or capillaries. This review is focussed on specific applications based on such types of experimental set-ups, from the macroscale where the tube acts only as an ordinary container down to the microscale where specific properties of the capillary come also into play.

2017-05

Hierarchical templating in deposition of semi-covalently imprinted inverse opal polythiophene film for femtomolar determination of human serum albumin

M. Dabrowski⁠, M. Cieplak⁠a⁠, P. Sindhu Sharma⁠, P. Borowicz⁠, K. Noworyta⁠, W. Lisowski⁠, F. D'Souza⁠⁠, A. Kuhn⁠, W. Kutner

Biosens.&Bioelectron. 2017, 94, 155-161

Nanostructured artificial receptor materials with unprecedented hierarchical structure for determination of human serum albumin (HSA) are designed and fabricated. For that purpose a new hierarchical template is prepared. This template allowed for simultaneous structural control of the deposited molecularly imprinted polymer (MIP) film on three length scales. A colloidal crystal templating with optimized electrochemical polymerization of 2,3′-bithiophene enables deposition of an MIP film in the form of an inverse opal. Thickness of the deposited polymer film is precisely controlled with the number of current oscillations during potentiostatic deposition of the imprinted poly(2,3′-bithiophene) film. Prior immobilization of HSA on the colloidal crystal allows formation of molecularly imprinted cavities exclusively on the internal surface of the pores. Furthermore, all binding sites are located on the surface of the imprinted cavities at locations corresponding to positions of functional groups present on the surface of HSA molecules due to prior derivatization of HSA molecules with appropriate functional monomers. This synergistic strategy results in a material with superior recognition performance. Integration of the MIP film as a recognition unit with a sensitive extended-gate field-effect transistor (EG-FET) transducer leads to highly selective HSA determination in the femtomolar concentration range.

2017-04

Efficient Annihilation Electrochemiluminescence of Cationic Helicene Luminophores

Haidong Li, Silvia Voci, Antoine Wallabregue, Catherine Adam, Geraldine M. Labrador, Romain Duwald, Irene Hernández Delgado, Simon Pascal, Johann Bosson, Jérôme Lacour, Laurent Bouffier, Neso Sojic

ChemElectroChem, 2017, in press, DOI: 10.1002/celc.201600906

The electrochemistry and annihilation electrochemiluminescence (ECL) of a series of chiral cationic helicene luminophores containing various substituents were investigated in acetonitrile as solvent. The electrochemical characterization evidenced a systematic reversible reduction of the cation whereas the oxidation could be reversible or not depending on the nature of the core heteroatoms within the structure as well as the functional group appendages. One of the key-parameters governing the ECL intensity is indeed the formal redox potentials for the electrogeneration of the neutral radical and dication radical species which will undergo the annihilation reaction. On that basis, a thermodynamic wall of efficiency was proposed in the case of ECL annihilation pathway to predict the formation efficiency of the emitting excited state and eventually light emission strength. This very simple wall is constructed by plotting the difference of formal potentials in function of the fluorescence wavelength delimiting thus two domains where ECL is thermodynamically possible or unfavorable. 

wall ECL

 

Spatially-resolved multicolor bipolar electrochemiluminescence

Haidong Li, Laurent Bouffier, Stéphane Arbault, Alexander Kuhn, Conor F. Hogan, Neso Sojic

Electrochemistry Communications, 2017, in press

Here, we describe a new aspect of multicolor potential-resolved electrochemiluminescence (ECL) based on bipolar electrochemistry (BPE). BPE involves a potential gradient established along a polarized conducting object which thus acts as a bipolar electrode (BE). The resulting driving forces can induce electron-transfer reactions, necessary for processes such as ECL occurring at different longitudinal locations along the same BE. In this work, we exploit the entire spatial domain where anodic polarization occurs to demonstrate for the first time how the potential gradient along a BE may be used to simultaneously resolve the emissions of ECL-active luminophores with differing oxidation potentials. The control of both size and position of the ECL-emitting domains was achieved by tuning the applied electric field. Multicolor light-emission was analyzed in detail to demonstrate spatial and spectral resolution of a solution containing different emitters. 

BP Multicolor

Co(III) Complexes of (1,3-Selen-2-yl)hydrazones and Their Sulphur Analogues: Comparative Structural, Electrochemical, Computational and Biological Activity Study

Nenad R. Filipović, Hana Elshaflu, Sonja Grubišić, Ljiljana S. Jovanović, Marko Rodić, Irena Novaković, Aleksandar Malešević, Ivana S. Djordjević, Haidong Li, Nešo Šojić, Aleksandar Marinković, Tamara R. Todorović

Dalton Trans., 2017, DOI: 10.1039/C6DT04785H

First Co(III) complexes with (1,3-selenazol-2-yl)hydrazones as an unexplored class of ligands were prepared and characterized by NMR spectroscopy and X-ray diffraction analysis. Novel ligands act as NNN tridentate chelators forming octahedral Co(III) complexes. The impact of structural changes on ligands' periphery as well as isosteric replacement of sulphur with selenium on electrochemical, and electronic absorption features of complexes are explored. To support the experimental data, density functional theory (DFT) calculations were also conducted. Theoretical NMR chemical shifts, the relative energies and natural bond orbital (NBO) analysis are calculated within the DFT approach, while the singlet excited state energies and HOMO-LUMO energy gap were calculated with time-dependent density functional theory (TD-DFT).  The electrophilic f and nucleophilic f+ Fukui functions are well adapted to find the electrophile and nucleophile centres in the molecules. Both, (1,3-selenazol-2-yl)- and (1,3-thiazol-2-yl)hydrazone Co(III) complexes showed potent antimicrobial and antioxidant activity. Significant difference among them was a smaller cytotoxicity of selenium compounds. 

 

Dernières news...

Capillary-assisted bipolar electrochemistry: a focused minireview


lundi 13 mars 2017
L. Bouffier, N. Sojic, A. Kuhn Electrophoresis, 2017, in press A bipolar electrode is quite unconventional as it behaves simultaneously as an anode and a cathode in contrast to a classic electrochemical setup where the electron-transfer reactions... Read More...

Hierarchical templating in deposition of semi-covalently imprinted inverse opal polythiophene film for femtomolar determination of human serum albumin


lundi 13 mars 2017
M. Dabrowski⁠, M. Cieplak⁠a⁠, P. Sindhu Sharma⁠, P. Borowicz⁠, K. Noworyta⁠, W. Lisowski⁠, F. D'Souza⁠⁠, A. Kuhn⁠, W. Kutner Biosens.&Bioelectron. 2017, 94, 155-161 Nanostructured artificial receptor materials with... Read More...

Spatially-resolved multicolor bipolar electrochemiluminescence


lundi 6 février 2017
Haidong Li, Laurent Bouffier, Stéphane Arbault, Alexander Kuhn, Conor F. Hogan, Neso Sojic Electrochemistry Communications, 2017, in press Here, we describe a new aspect of multicolor potential-resolved electrochemiluminescence (ECL) based on... Read More...

Co(III) Complexes of (1,3-Selen-2-yl)hydrazones and Their Sulphur Analogues: Comparative Structural, Electrochemical, Computational and Biological Activity Study


lundi 6 février 2017
Nenad R. Filipović, Hana Elshaflu, Sonja Grubišić, Ljiljana S. Jovanović, Marko Rodić, Irena Novaković, Aleksandar Malešević, Ivana S. Djordjević, Haidong Li, Nešo Šojić, Aleksandar Marinković, Tamara R. Todorović Dalton Trans., 2017,... Read More...

Efficient Annihilation Electrochemiluminescence of Cationic Helicene Luminophores


vendredi 3 février 2017
Haidong Li, Silvia Voci, Antoine Wallabregue, Catherine Adam, Geraldine M. Labrador, Romain Duwald, Irene Hernández Delgado, Simon Pascal, Johann Bosson, Jérôme Lacour, Laurent Bouffier, Neso... Read More...

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