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mardi 25 avril 2017

Hierarchical templating in deposition of semi-covalently imprinted inverse opal polythiophene film for femtomolar determination of human serum albumin

M. Dabrowski⁠, M. Cieplak⁠a⁠, P. Sindhu Sharma⁠, P. Borowicz⁠, K. Noworyta⁠, W. Lisowski⁠, F. D'Souza⁠⁠, A. Kuhn⁠, W. Kutner

Biosens.&Bioelectron. 2017, 94, 155-161

Nanostructured artificial receptor materials with unprecedented hierarchical structure for determination of human serum albumin (HSA) are designed and fabricated. For that purpose a new hierarchical template is prepared. This template allowed for simultaneous structural control of the deposited molecularly imprinted polymer (MIP) film on three length scales. A colloidal crystal templating with optimized electrochemical polymerization of 2,3′-bithiophene enables deposition of an MIP film in the form of an inverse opal. Thickness of the deposited polymer film is precisely controlled with the number of current oscillations during potentiostatic deposition of the imprinted poly(2,3′-bithiophene) film. Prior immobilization of HSA on the colloidal crystal allows formation of molecularly imprinted cavities exclusively on the internal surface of the pores. Furthermore, all binding sites are located on the surface of the imprinted cavities at locations corresponding to positions of functional groups present on the surface of HSA molecules due to prior derivatization of HSA molecules with appropriate functional monomers. This synergistic strategy results in a material with superior recognition performance. Integration of the MIP film as a recognition unit with a sensitive extended-gate field-effect transistor (EG-FET) transducer leads to highly selective HSA determination in the femtomolar concentration range.

2017-04

Capillary-assisted bipolar electrochemistry: a focused minireview
lundi 13 mars 2017
L. Bouffier, N. Sojic, A. Kuhn Electrophoresis, 2017, in press A bipolar electrode is quite unconventional as it behaves simultaneously as an anode and a cathode in contrast to a classic... Read More...
Hierarchical templating in deposition of semi-covalently imprinted inverse opal polythiophene film for femtomolar determination of human serum albumin
lundi 13 mars 2017
M. Dabrowski⁠, M. Cieplak⁠a⁠, P. Sindhu Sharma⁠, P. Borowicz⁠, K. Noworyta⁠, W. Lisowski⁠, F. D'Souza⁠⁠, A. Kuhn⁠, W. Kutner Biosens.&Bioelectron. 2017, 94, 155-161...
Spatially-resolved multicolor bipolar electrochemiluminescence
lundi 6 février 2017
Haidong Li, Laurent Bouffier, Stéphane Arbault, Alexander Kuhn, Conor F. Hogan, Neso Sojic Electrochemistry Communications, 2017, in press Here, we describe a new aspect of multicolor... Read More...
Co(III) Complexes of (1,3-Selen-2-yl)hydrazones and Their Sulphur Analogues: Comparative Structural, Electrochemical, Computational and Biological Activity Study
lundi 6 février 2017
Nenad R. Filipović, Hana Elshaflu, Sonja Grubišić, Ljiljana S. Jovanović, Marko Rodić, Irena Novaković, Aleksandar Malešević, Ivana S. Djordjević, Haidong Li, Nešo Šojić, Aleksandar... Read More...
Efficient Annihilation Electrochemiluminescence of Cationic Helicene Luminophores
vendredi 3 février 2017
Haidong Li, Silvia Voci, Antoine Wallabregue, Catherine Adam, Geraldine M. Labrador, Romain Duwald, Irene Hernández Delgado, Simon Pascal, Johann... Read More...
Applications of Electrogenerated Chemiluminescence in Analytical Chemistry
mercredi 18 janvier 2017
N. Sojic, S. Arbault, L. Bouffier, A. Kuhn Luminescence in Electrochemistry. Applications in Analytical Chemistry, Physics and Biology. Eds. F. Miomandre, P. Audebert, 2017. Springer. The great... Read More...
Recent Advances in Bipolar Electrochemistry
jeudi 12 janvier 2017
L. Bouffier, D. Zigah, N. Sojic, A. Kuhn Electroanalytical Chemistry: A Series of Advances, Volume 27, eds. A.J. Bard, C.G. Zoski, 2017, CRC Press, Taylor&Francis Group, in press The concept of... Read More...
Low-Molecular-Weight Hydrogels as New Supramolecular Materials for Bioelectrochemical Interfaces
jeudi 12 janvier 2017
D. Jain, A. Karajic, M. Murawska, B. Goudeau, S. Bichon, S. Gounel, N. Mano, A. Kuhn, P. Barthélémy ACS Appl. Mater. Interfaces 2017, in press, DOI: 10.1021/acsami.6b12890 Controlling the... Read More...
Highly Ordered Macroporous Electrodes
jeudi 12 janvier 2017
A. Kuhn, M. Heim Springer Handbook of Electrochemical Energy, eds. C. Breitkopf, K. Swider-Lyons, Chapter 6 p143-206, Springer Verlag, Berlin 2017, ISBN:978-3-662-46656-8 In this book chapter, we... Read More...
Full-Spectral Multiplexing of Bioluminescence Resonance Energy Transfer in Three TRPV Channels
jeudi 12 janvier 2017
H. J. Ruigrok, G. Shahid, B. Goudeau, F. Poulletier de Gannes,E. Poque-Haro, A. Hurtier, I. Lagroye, P. Vacher, S. Arbault, N. Sojic, B. Veyret, Y. Percherancier Biophysical Journal, 2017, 112,... Read More...
Bright Electrochemiluminescence Tunable in the Near-Infrared of Chiral Cationic Helicene Chromophores
mercredi 11 janvier 2017
Haidong Li, Antoine Wallabregue, Catherine Adam, Geraldine M. Labrador, Johann Bosson, Laurent Bouffier, Jérôme Lacour, Neso Sojic J. Phys. Chem. C,... Read More...
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